Endocrine Abstracts

Introduction: Acromegaly is a chronic disease associated with impairment of quality of life (QoL) and psychological status. The aim of the present study was to assess QoL and mood disturbance in patients with acromegaly.Description of methods/design: It was a comparative, cross-sectional study conducted in the department of Endocrinology at a tertiary medical centre of northern Greece in 2011. AcroQoL questionnaire was used to assess QoL in acromegalics ...

Background: Acromegaly is a rare disorder, with a prevalence of 6 cases of 100000 and an annual incidence of 3–4 new cases of one million. It is almost always the consequence of GH secreting pituitary adenomas and, rarely, caused by nontumoral somatotrophic hyperplasia.Case presentation: 54 years old patient, heavy smoker, hypertensive, dyslipidemic, obese, presents in June 2019 with unspecific symptoms: physical asthenia, hypersomnia (falls asleep ...

Introduction: The prevalence and comorbidities of NAFLD in CD are unknown. There is only one study wich set the prevalence of NAFLD by CT images in 20%1.Objectives: Describe the prevalence of NAFLD and fibrosis in CD and analize predictive biomarkers of NAFLDMethods: Transversal descriptive study. 31 patients with CD; 11 active, 20 cured. Women 24 (77%), men 7 (23%). 54 years mean age. NAFLD was valorated by Hepatic Stea...

The GH-receptor antagonist PEG, used as monotherapy or in combination to SA, has been demonstrated to normalize IGF1 levels in up to 90% of acromegalic patients after unsuccessful surgery and/or radiotherapy and resistant to conventional SA treatment. The aim of this study is to evaluate the efficacy and safety of combined treatment with SA plus PEG in a cohort of acromegalic patients resistant to conventional SA therapy. Thirty-two acromegalic patients (17 M, 15 F, age 39.6&#...

Background: Mitotane is the only drug approved for the treatment of adrenocortical carcinoma (ACC). Although adverse effects (AEs) associated to its use are frequent, detailed information are very limited. Aim was to evaluate the AEs of mitotane monotherapy in ACC patients. Methods: We performed a retrospective multicenter study including 311 ACC patients (F=200, median age 49 yrs) treated with mitotane as first line of medical treatment. Presence and grade of AEs were collect...

Background: During the past decades, the prevalence of both obesity and differentiated thyroid carcinoma increased worldwide. The link between obesity and thyroid cancer is controversial. Some studies found a relationship between obesity and thyroid carcinoma (especially BRAFV600E mutated) and between type 2 diabetes mellitus and thyroid cancer, while other did not. Aim: To assess the relationship between papillary thyroid carcinoma and increa...

Recent studies have reported a high prevalence of USP8 mutations in corticotroph adenomas causing Cushing’s disease. Nelson’s syndrome is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory Cushing’s disease that is caused by the development of an ACTH-secreting tumor in the pituitary gland. Whether USP8 alterations are also present in Nelson’s tumors has not been studied in detail so far....